Brand Story
R&D STORY
Drawing on traditional wisdom and clinical evidence, we are setting a new standard for cognitive health.
MT104
A cognitive health ingredient developed based on traditional wisdom and clinical evidence
It began with the time-honored wisdom of traditional Korean medicine.
The wisdom is carried forward through science exploring the gut-brain axis.
Significant effects were demonstrated compared with placebo.
MT104 is a cognitive health ingredient developed by Mthera Pharma. Products featuring this ingredient are planned for launch.
Why Mthera Pharma Is Developing MT104
Mthera Pharma is a biopharmaceutical company dedicated to botanical new drug discovery and development. Leveraging the rigorous research standards and expertise of drug development, we develop clinically validated ingredients.
1
We are independently developing three clinical-stage botanical drug pipelines targeting chronic and difficult-to-treat diseases.
2
Based on Cuscuta japonica Choisy and L. paracasei NK112, MT104 is supported by patent protection and clinical proof-of-concept data.
3
We have experience independently designing and conducting multicenter, randomized, double-blind clinical trials in accordance with FDA and MFDS requirements.
4
We apply the same GMP and quality management standards used in drug development throughout the entire ingredient manufacturing process.
MT104 — Powered by Mthera Pharma’s Expertise and Technology
When it’s hard to recall what was just said
When important names or dates keep slipping your mind
When you become concerned about increasing forgetfulness with age
Traditional Korean Medicine
Representing replenishing vital essence and nourishing the marrow — in traditional medicine, the brain is regarded as the "Sea of Marrow (髓海)."
Modern Science
Reinterpreting the traditional concept of “nourishing the Marrow” through modern science, with scientific evidence supporting mechanisms related to neuronal protection and brain activity.
* This statement describes the interpretation of a traditional Korean medicine concept through modern scientific research and does not intend to diagnose, treat, cure, or prevent any specific disease.
The gut and the brain communicate bidirectionally through the "Gut-Brain Axis."
Probiotics that may support mental well-being are referred to as “psychobiotics.”
Suppression of harmful gut microbiota
Blocking the translocation of toxins and inflammatory factors to the brain
Reduction of neuroinflammation (e.g., NF-κB, IL-6)
Increased expression of BDNF (Brain-Derived Neurotrophic Factor)
Support for neuronal protection and growth
Improvement in behaviors associated with memory impairment and cognitive decline
* These descriptions are based on mechanistic studies of the strain. Functional claims for the final product will be limited to those recognized by the Korean Ministry of Food and Drug Safety (MFDS).
Gut health and cognitive function are not separated
5 SCI-Indexed Papers Published on MT104 and Its Core Ingredients
1
Restores balance to the gut microbiome to foster a comfortable, healthy intestinal environment.
2
Through the gut-brain axis, signals from the gut may naturally extend to the brain.
3
Helps support overall cognitive wellness, including memory retention and mental clarity.
From Gut Care to Memory Support, MT104 Is with You Every Step of the Way.
Results of a Spatial Memory Test in an Alzheimer’s Disease Mouse Model (5xFAD) · Animal Study Biomed Pharmacother. 2023 Feb;158:114105
Alzheimer’s (non-treated)
The mice struggled to navigate through the water and took considerably longer to locate the target platform.
Alzheimer's + MT104
The MT104-treated group located the target at a speed comparable to that of the normal group.
After five days of learning trials, the MT104-treated group showed an improvement In navigation speed comparable to that of the normal group.
# Significant difference vs. Normal group * Significant improvement vs. Alzheimer’s group
Morris Water Maze: A representative animal behavioral test used to evaluate spatial learning and memory.
Elevated inflammatory signals under intestinal stress were reduced toward normal levels following MT104 administration. Biomed Pharmacother. 2023 Feb;158:114105
When the gut is under stress
inflammatory signals increase
With MT104 administration, they decrease toward normal levels
Lower bars indicate lower levels of inflammatory signals.
# Significant increase/difference vs. the Normal group * Significant improvement in the MT104-treated group vs. the untreated Alzheimer’s disease group
GFAP: Marker of inflammatory reactivity · TLR2 · CCR2: Markers associated with inflammatory signaling
12-Week Administration · Multi-Center · Randomized · Double-Blind · Placebo-Controlled Human Clinical Trial J Medi Food. 2025 Aug;28(8):812-823
Higher scores indicate greater improvement in cognitive function.
*p<0.05 (Compared to placebo, ANCOVA)
Higher scores indicate greater improvement in memory performance.
*p<0.05 (Compared to placebo, ANCOVA)
K-MoCA: Korean Montreal Cognitive Assessment · SNSB-SVLT: Seoul Neuropsychological Screening Battery-Seoul Verbal Learning Test, an assessment of verbal memory
Choline Alfoscerate human clinical study reference: BMC Geriatr. 2024 Sep 19;24(1):774
MT104
A New Standard in Cognitive Health · COMING SOON
Demonstrated recovery to normal levels in Alzheimer's animal models
Confirmed reduction in neuroinflammation mediated by the Gut-Brain Axis.
Both K-MoCA and verbal memory scores showed significant improvements compared with placebo.
MT104 — Mthera Pharma’s new standard in cognitive health. Be the first to hear about its launch.
